It all depends what kind of fit is required & if you are using a manual or CNC milling machine. It also depends on the size of the hole & if it is a standard or special thread. We machined Inconel 718 all the time for rotating aircraft engine parts but none of our holes were tapped.
Thread mill. I never tap in hard material. If it would happen to break inside, you could fish it out compared to a tap. You can also dial in the thread fit and feel.